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The observed protective effect of riboflavin against oxidative damage of lipids, proteins and nucleic acids could be mediated by the enhanced activity of antioxidant enzymes which have been reported to occur concurrent with the reduced levels of MDA (Reference Al-Harbi, Imam and Nadeem22Reference Btn, Nazrolu and Demirci24,Reference Bashandy, Ebaid and Moussa26,Reference Naseem, Hassan and Alhazza28,Reference Salman and Naseem29,Reference Jiang, Chen and Liu33,Reference Tang, Wen and Guo36) , 8-hydroxydeoxyguanosine (Reference Karakoyun, Erta and Yksel27,Reference Sakarcan, Erahin and Eminolu30) and protein carbonyl (Reference Alhazza, Hassan and Ebaid23,Reference Naseem, Hassan and Alhazza28,Reference Jiang, Chen and Liu33)

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Gadolinium blocks ATP and ADP hydrolysis, increases the vascular reactivity of rat aortic rings to phenylephrine via stimulation of angiotensin II AT1 receptors, and reduces nitric oxide bioavailability (Angeli et al

This flavanone is subsequently hydroxylated by flavonoid 3-hydroxylase (F3H) to form a dihydroflavonol, such as dihydromyricetin

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