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Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-B signaling pathway

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In addition to an antioxidant role, AA acts at the molecular level as a cofactor for enzymes such as dopamine hydroxylase (EC 1.14.17.1), influencing the concentration of neurotransmitters, improving lysosomal protein degradation and mediating the consumption of monosodium glutamate (MSG) [43]

Autophagy, on the other hand, involves the degradation of damaged organelles or proteins through autophagosomes, and while it can be protective under stress conditions, excessive autophagy can also lead to cell death

By identifying genetic vulnerabilities and measurable biochemical imbalances early, families can implement targeted nutritional and supplemental strategies alongside therapies