b12 injection site pain What Are Injections and How Do They Work? Vitamin B12 Shot - Delaware:

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6 Reduced levels of B12 and folate compromise the bodys ability to convert homocysteine to methionine, leading to elevated homocysteine

Neural tube defects like spina bifida and anencephaly can be devastating or fatal to a baby

Best for: MTHFR mutations (C677T, A1298C) Supporting methylation directly Neurological symptoms (brain fog, neuropathy) Depression and mood disorders Elevated homocysteine Advantages: No conversion required immediately bioavailable Directly supports methylation cycle Crosses blood-brain barrier easily Lowers homocysteine effectively Potential downsides: Can cause overmethylation symptoms in sensitive individuals (anxiety, insomnia, irritability) May need to start with very low doses Not ideal for those with histamine issues or overmethylators Typical dosage: 500-5000mcg daily (start low) 2

M.de la ChapelleA.et al (2004)