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doi:10.1038/s41593-023-01395-4

Upon the cleavage, positively charged primary amines are generated, facilitating the effective crossing of the nanoprobe through BBB via the adsorption-mediated transcytosis pathway, while avoiding the caveat of cationic toxicity

But I wouldn't make a policy until we know Strengthening immunity with two doses of different vaccines could also garner a better protection against the COVID-19 variants