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When B12 deficiency impairs DNA synthesis, the rapidly dividing epithelial cells cannot regenerate effectively, leading to mucosal thinning, increased fragility, and susceptibility to ulceration

This built-in safety mechanism prevents excessive growth hormone production and maintains natural regulatory systems

2021;2021:1815098 Onay-Besikci A, Altarejos JY, Lopaschuk GD

Tsao, H.-M

In addition, purinoreceptor subtype 7 activation has been observed to cause caspase-1 activation, which is ultimately involved in the expression of cyclooxygenase 2 and prostaglandin E2 and IL- production