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In addition, STAT3 can regulate the membrane expression of a variety of mitochondrial and cell membrane-related genes, thereby affecting mitochondrial function and cell membrane integrity, thereby affecting cell survival and death

doi: 10.3390/jcm8040561

This antitumor effect could be reversed by aspartate supplementation [26], reinforcing that the presence of other metabolites (in this case, another amino acid) in the TME can influence the effects of a single one in tumor biology

After inducing ischemic AKI in 810-week-old, male C57BL/6 mice, mass spectrometry metabolomics revealed that the liver had the most distinct phenotype 24 h after AKI versus 4 h and 7 days

doi: 10.1038/s41577-022-00792-3 140 MadsenPMDesuHLde Rivero VaccariJPFlorimonYEllmanDGKeaneRWet al