is inducing glutathione pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs Dietary pro-oxidant therapy by a

Similarly, significant protein carbonyl accumulation was observed in ARPE-19 cells (derived from human RPE cells) following blue light exposure (430 nm, 1.5 mW/cm 2 , 20 min) in the presence of accumulated A2E, with protein carbonyl levels increasing by up to several dozen times relative to nonirradiated controls 165

In the context of ferroptosis, ChaC1 degradation of GSH enhances susceptibility to ferroptosis under cystine starvation conditions (Wang et al., 2019)

Abdulla D, Ali Y, Menezo V, Taylor SRJ (2022) The use of sustained release intravitreal steroid implants in non-infectious uveitis affecting the posterior segment of the eye

xCT inhibition increases sensitivity to vorinostat in a ROS-dependent manner

Given that these basal metabolic processes are putatively present in both groups of this study and no indications exist that these could play a role in tinnitus pathophysiology, we surmise that this possible confounder can be ruled out in the presented results and the found differences between groups represent true effects