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Interestingly, this pathogen expresses lipoxygenase (which oxidizes AA-PE to 15-hydroperoxide AA-PE in host cells) and drives ferroptosis in human bronchial epithelial cells, as well as in clinically isolated cells from patients with persistent lower respiratory tract infection

As single-cell and multi-omics technologies continue to mature, researchers will increasingly be able to profile DNA methylation, histone modifications, chromatin accessibility, and gene expression within the same cell, thereby generating a more accurate picture of epigenetic changes associated with depression and addiction 186,187

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