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Among the macrophage populations in obese adipose tissue, lipid-associated macrophages (LAM) form a cluster with a distinct transcriptional signature related to lipid metabolism and phagocytosis, and their numbers increase during the progression of obesity

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Moreover, OS can activate various signaling pathways, including the NF-B pathway, which promotes the expression of pro-inflammatory cytokines such as TNF- and IL-6, further contributing to neuroinflammation and neuronal apoptosis (Sharan et al., 2024)