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Conclusions and future perspective Despite a large part of literature exploring on the accumulation and the origin of ROS, current antioxidant-based therapies lack of specificity for dysfunctional tissues, cells, and organelles, and thus may not reach an effective concentration at the target site of pathologic oxidative stress

4 Ferroptosis defense systems 4.1 SLC7A11-GSH-GPX4 axis The main barrier that inhibits the path of ferroptosis is the redox of the cell, which is that it can instantly remove membrane phospholipid peroxide

The observations demonstrated that baicalin enhanced glucose disposal by increasing GS activity, potentially due to upregulated GS expression instead of direct activation by baicalin

Late-life depression and risk of vascular dementia and Alzheimers disease: systematic review and meta-analysis of community-based cohort studies

doi: 10.1016/j.anireprosci.2015.08.012 71