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International Investigative Dermatology 2013 Kaken Pharmaceutical Co., Ltd

However, avoid using GHK-Cu at the same time as highly acidic products (like low-pH Vitamin C or AHAs), as acids can break the bond between the peptide and the copper ion, making it less effective

doi: 10.3389/fphar.2025.1524654 Received 08 November 2024 Accepted 29 April 2025 Published 14 May 2025 Volume 16 - 2025 Edited by Hua Li, Air Force Medical University, China Reviewed by Xie-an Yu, Shenzhen Institute For Drug Control, China Bing Yu, Second Military Medical University, China Updates Copyright 2025 Ma, Chu, Quan, Li, Zhou, Han, Li, Pan, Wang, Yan, Shu and Qiao

Side effects, safety & contraindications In trials the most commonly reported side effects were gastrointestinal, including nausea, vomiting, constipation, and decreased appetite, generally described as dose-related and more frequent during dose escalation

In medicine, tyrosinase is a key therapeutic target for treating a range of skin pigmentation disorders, including vitiligo 17 , hyperpigmentary 18,19,20,21 , and melanoma 22