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Furthermore, amplifications of clinically actionable target genes such as ERBB2 and myeloid leukaemia cell differentiation protein (MCL1) are also common in brain-tropic metastatic cells

However, the presence of conserved amino acids in the shared motif between Zot and zonulin lead these researchers to synthesize an octapeptide, now known as LA, with the same amino acid sequence as the NH 2 -terminus of human fetal zonulin, positions 815 (7)