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Accordingly, these findings show the beneficial effect of crude HEM in promoting OL maturation and myelination in the white matter of developing brains

However, curcumin administration demonstrated effectively counteracted retinal degeneration, preventing alterations in the apoptotic cascade, MAPK, and small ubiquitin-like modifier 1 (SUMO-1) pathways, this therapeutic intervention preserved RGC viability and maintained normal histological architecture by stabilizing critical protein degradation mechanisms [42]

10.1016/S0168-9525(00)02140-5 13

LSCK was completely ground by using the frozen tissue grinder (Wonbio-96C, Shanghai Wanbo Biotechnology, Shanghai, China) for 6 min at 10C and 50 Hz