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Studies have shown that DAP and reuterin can inhibit the heterodimerization of HIF-2 with the aryl hydrocarbon receptor nuclear translocator, thereby downregulating the expression of intestinal iron absorption-related genes and subsequently limiting iron uptake ( 5-MIAA has been shown to activate Nrf2 ( Lactobacillus leads to decreased circulating levels of these metabolites, which in turn attenuates the inhibition of intestinal iron absorption ( 4.2.5 Oxidative stress and inflammatory response An increased abundance of Gram-negative bacteria in the gut of PCOS patients elevates circulating LPS, which activates the LPS/TLR4 pathway and sustains systemic chronic low-grade inflammation ( During PCOS progression, persistent inflammation also induces mitochondrial dysfunction, uncouples the electron transport chain, and promotes substantial ROS leakage ( 4.2.6 Interplay and hierarchical roles of microbial metabolites Gut microbiota dysbiosis in PCOS patients leads to a reduction in bacteria that produce SCFAs and metabolize BAs, resulting in decreased levels of protective metabolites such as SCFAs and BAs

The Journal of nutrition, 128(7), 1204-1212

J Trace Elem Med Biol 52:100110

Its soft pink hue comes from naturally derived vitamin B12 (cyanocobalamin)

Argent Microbiol