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Local and Theoretical Concerns Local reactions observed or theoretically expected in animal models include: Transient erythema at topical application sites Mild irritation or inflammatory responses at injection sites Potential for altered MMP activity with excessive dosing Theoretical risk of excessive collagen degradation if matrix enzyme balance is disrupted The concern about copper toxicityvalid for free copper ionsappears mitigated by the peptides chelation mechanism

Crim MC, Calloway DH, Margen S (1975) Creatine metabolism in men: urinary creatine and creatinine excretions with creatine feeding

Pollution, aging, smoking, stress, alcohol, and UV rays all contribute to oxidative stress

Wear protective gloves, some sealers are harder to remove from skin once dried

Rosenow J, Das K, Rovit RL, Couldwell WT