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However, the activation of the initiator of the extrinsic pathway, caspase-8, was similar between AS and WT NPCs (Fig

doi: 10.3109/00498254.2013.845705 66

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and RSL3, which targets GPX4) overcomes this limitation: the combination suppresses the mTOR4EBP1 axis to inhibit RCC cell activity and induce ferroptosis, offering a promising option for drug-resistant mRCC (260)