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The use of statins may protect HNSCC patients against adverse outcomes, particularly HPV-positive patients (Getz et al., 2021), and may enhance responses to PD-1 checkpoint blockade and other HNSCC immunotherapies by modifying the HNSCC tumor immune microenvironment (Kansamurine modelsl et al., 2023)

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It is precisely because of this potency that many of these compounds are experimental, not approved for human use and often banned in sporting competitions