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2+ in the iron pool generates a considerable volume of hydroxyl radicals and ROS through the Fenton reaction, which causes ferroptosis (Figure 1B) (Frazer and Anderson, 2014

Separate PCA in patient and control groups identified three similar components with the same metabolite loadings exceeding 0.5 on corresponding components in each group

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Thus it is possible that both Gh_A12G2084 and Gh_D12G2260 have two transcripts, Gh_A12G2084 and Gh_D12G2260 represented putative GhGPX10 and GhGPX9 , respectively