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Using the wrong diluent can introduce contaminants or alter the solution's pH, leading to aggregation (clumping) or degradation

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doi: 10.1523/JNEUROSCI.5413-09.2010 33 EckerC.SpoorenW.MurphyD

Accordingly, in the CY 2025 OPPS/ASC final rule with comment period, we finalized a policy to exclude the non-opioid treatments for pain relief identified as satisfying the required criteria for payment under section 4135 of the CAA, 2023 from the C-APC policy to ensure payment is not packaged into any C-APC and that separate payment is made in accordance with the statute (89 FR 93938 through 93939)