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Description

In NSCLC (A549, H1650, H460, H1975, PC-9, H1299, and CCD-19Lu) cells, it inhibits KRAS mutant cell lines by reducing secretory phospholipase A2-IIa (sPLA2-IIa) and NF- B pathway activity, while inhibiting mTOR and AKT while activating AMPK [473]

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10.1016/0378-1119(94)90324-7 59 SchneiderJ.NiermannK.WendischV

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The transient methods, necessary to survey the large number of mutants in this project, introduce considerable measurement noise originating with variable level expression and brightly fluorescent dead cells

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