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doi: 10.1128/iai.00813-19 28 RichardNMartiLVarrotAGuillotLGuitardJHennequinCet al

While a limited amount of research suggests athletes may benefit from their use, other studies have been less positive

In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms