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The nucleophilic sulfur atom of the cysteine moiety of GSH serves as a mechanism to protect cells from harmful effects induced by toxic electrophiles

Int J Mol Sci 2023;24(12):9885

4.2 Reduced glucotoxicity and lipotoxicity Glucotoxicity is characterized by irreversible tissue and cell damage resulting from insulin resistance and persistently elevated glucose levels stemming from excessive carbohydrate intake (Mota et al., 2016)