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In addition, as HIF-1 can also actively repress mitochondrial aerobic metabolism through PDK1 (Papandreou et al., 2006), interruption of the TCA cycle could explain lower levels of ATP in KRAS G13D/ cells compared with KRAS G13D/+ and KRAS cells

These patients usually present early in life (usually in infancy) as severe or life threatening bacterial or fungal infections

-Synuclein in synaptic function and dysfunction

ATF4 overexpression alleviated SA-induced hepatotoxicity, whereas ATF4 silencing accelerated cell death

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