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Kumar Santra, B

The COX-2-PGE2 signaling cascade plays a crucial role in modulating the tumor microenvironment (TME) by influencing immune cell polarization, activating cancer-associated fibroblasts, and promoting ECM remodeling, angiogenesis, and T cell exclusion

Science 262 , 10191024 (1993)

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Therefore, when cephalosporins are used in the treatment of patients with pelvic inflammatory disease and Chlamydia trachomatis is one of the suspected pathogens, appropriate antichlamydial coverage should be added