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It also compromises the efficacy of chemotherapeutics, particularly weak base drugs like doxorubicin and vincristine, through ion trapping that reduces their intracellular concentration and by increasing the efflux activity of the p-glycoprotein (99101)

Nishimura Y, Kanda Y, Sone H, Aoyama H

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The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults