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By defining global and gene-specific DNA 5hmC modifications, we demonstrated that DMF induces 5hmC modifications to influence loci-specific chromatin structure through L2HGDH to reduce the levels of L2HG

Doubling doses: Does not improve results and may cause side effects

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These signaling networks orchestrate cytokine release, leukocyte recruitment, endothelial activation, apoptosis, and fibrotic remodeling, ultimately contributing to sustained renal damage and impaired recovery (Wang et al