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Yoshihara T, et al

A group at the Walter Reed Army Institute of Research (WRAIR) created prefusion-stabilized S-trimer-ferritin nanoparticles (SpFNs) , which were shown to be stable candidate immunogens that elicited potent nAb titers against SARS-CoV-2 variants and robust protection against challenge in a K18-hACE2 mouse model [128, 129] (Table 3)

Being similar to a naturally occurring substance does not guarantee that an injected product is safe

The lyophilisation process removes water content to below 3%, which eliminates hydrolytic degradationthe primary pathway through which peptide bonds break down at ambient temperatures

The natural pulsatile pattern of GH secretion appears to be important for some of GHs effects lipolysis, for example, responds more robustly to pulsatile GH than to constant GH levels