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The liver has a central role in the metabolism of fatty acids (FA) and triglycerides (TGs), shifting between synthesis and breakdown in response to the fed and fasted states

Glutamate signaling in hepatic stellate cells drives alcoholic steatosis

Your pituitary still controls how much hormone is released, so you cannot easily overshoot natural levels

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It is postulated that neurotransmitters or neurochemicals released by nerve endings, specifically substance P, can be toxic to melanocytes, causing their destruction in specific areas.92,93 The segmental distribution of vitiligo patches corresponds to the innervation of certain nerves, supporting this hypothesis.92,93 A study analyzing the presence of VZV in segmental vitiligo skin suggests a possible relationship between the 2