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[DOI] [PubMed] [Google Scholar] 22.Luyendyk J.P., Kassel K.M., Allen K., Guo G.L., Li G., Cantor G.H., Copple B.L

Metabolic Switching: By activating AMPK, Berberine effectively mimics the metabolic state of exercise, increasing muscle glucose uptake and reducing hepatic glucose production, thereby stabilizing blood sugar balance

SIRT1 activation improves insulin sensitivity, enhances fat oxidation, and promotes mitochondrial biogenesis

Previous bariatric surgery Patients with any history of gastric bypass, sleeve gastrectomy, or other bariatric procedures require lifelong b12 monitoring and supplementation