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Role of compartmentation in promoting toxicity of leukocyte-generated strong oxidants

Cell (2008) 133:77587.10.1016/j.cell.2008.05.009 41 MichalekRDGerrietsVAJacobsSRMacintyreANMacIverNJMasonEFet alCutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets

Mutations in the MTHFR gene, such as C677T or A1298C, can reduce enzyme efficiency, leading to elevated homocysteine and disrupted methylation pathways