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An array of studies has demonstrated a significant correlation between sorafenib resistance and the onset of ferroptosis in hepatocytes, with multiple key molecules of the ferroptosis pathway implicated in the initiation, progression, and prognosis of HCC

Despite recent developments in the field of metal-based catalytic drugs, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses 29

Several members of GmGST revealed tissue-specific expression during the transcript profiling for 74 GmGST genes

GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring peptide found in human plasma and tissues

Copper peptides are naturally occurring compounds that promote collagen synthesis, improve skin elasticity, and assist in wound healing