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The condition affects roughly 1 to 3% of the general adult population, with peak incidence occurring between ages 30 and 50

Hepatocyte injury triggered by ER stress, mitochondrial dysfunction, or xenobiotics produces ROS, mitochondrial DNA, and apoptotic bodies that activate Kupffer cells (KCs) and HSCs (HSCs)

Methods: Publications related to the topic from 2008 to 2025 were retrieved from the WOSCC and PubMed databases

Invest., 2000, 106: 1071-1075, which is expressly incorporated by reference herein, in its entirety Supermir A supermir refers to a single stranded, double stranded or partially double stranded oligomer or polymer of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) or both or modifications thereof, which has a nucleotide sequence that is substantially identical to an miRNA and that is antisense with respect to its target

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