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A ROS-sensitive hydrogel constructed by Zhang et al., which expresses a photosensitizer and an anti-CD47 antibody, alters the function of TAMs and T cells, thereby promoting anti-tumor immunity in cold tumors that typically respond poorly to ICIs [232]

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In addition to PK changes, pharmacodynamic alterations in older adults, such as reduced receptor sensitivity and impaired enzyme function, can modify the response to therapeutic agents