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TAMs also express the checkpoint inhibitor PD-L1, which binds to its receptor PD-1 on activated T lymphocytes and drives cell apoptosis 269

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In multiple dose studies in hypertensive patients with stable renal insufficiency and patients with renovascular hypertension, valsartan had no clinically significant effects on glomerular filtration rate, filtration fraction, creatinine clearance, or renal plasma flow