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Accordingly, we hypothesized that inhibition of RNR function may suppress ferroptosis by reducing the draw on the existing GSH pool, which can then be re-routed to suppress ferroptosis

Presented at the JSSX/ISSX Meeting, Maui, HI October 2005

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Over time, the duration and frequency of these flares may increase, resulting in chronic gouty arthritis and subcutaneous deposits of crystals, referred to as tophi, both of which can lead to the destruction of joints and musculoskeletal disability

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