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Its effects require intact amylin receptor signaling, as demonstrated in receptor knockout models where weight loss is abolished, and structural studies show unique conformational dynamics at these receptors compared to native amylin or other analogs

After 24 h media was replaced by fresh medium and further incubated for 3 days

Carcinoma 10, 21732185

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Impaired cell signaling pathways also disrupt this cycle, and once this happens, pigment can no longer be regenerated, leading to permanent greying