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2020 May-Jun, Volume 25 (Issue 3), Pages 1361-1367

3.2.1 Steroidogenic enzyme inhibition 3.2.1.1 17-hydroxysteroid dehydrogenase (HSD17B) suppression Cadmium exposure directly inhibits HSD17B enzymatic activity with an IC50 of 2.2 M, resulting in an 85% reduction in testosterone synthesis capacity