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The mevalonate pathway in neurons: its not just about cholesterol

66,72,73 Central auditory hyperactivity is further amplified by decreased inhibitory neurotransmission, altered receptor expression, and increased excitatory drive, which may be reinforced by spike-timing-dependent plasticity

Science 300 , 342344 (2003)

The first change seen is endothelial activation, which is characterized by an aberrant pro-inflammatory and pro-thrombotic phenotype of blood vessel endothelial cells