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In high-fat diet-induced diabetes mice, administration of liraglutide activated pancreatic and duodenal homeobox-1 (Pdx-1), an essential regulator of proliferation and function of pancreatic -cells [56]

Therefore, it seemed logical to consider their potential use in treating autoimmune diseases, where B cells play a relevant role, such as systemic lupus erythematosus or systemic sclerosis, among others ( Table 1 )