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doi: 10.1139/cjpp-2014-0387 102

Based on current study findings, DOX-induced acute nephrotoxicity may be prevented by administration of ORES and/or DAPA through changes to the PPAR-/Nrf-2/HO-1, NF-B/TNF-/Keap-1, and Bcl-2/Caspase-3/ATG-5 pathways

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discovered that incorporating amorphous heptapeptide DEETGEF into the SLNs induced the activation of NQO1 (NADPH quinone oxidoreductase), HMOX1 (Heme oxygenase-1), and PRDX1 (Peroxiredoxin-1) genes, which function as cell-protecting enzymes