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STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer

At the core of the mammalian molecular circadian clock, the transcription factors CLOCK and BMAL1/NPAS form a heterodimer that activates the expression of clock-controlled genes by binding to E-box elements, initiating the cycle

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Specifically, the results showed that probiotics have the potential to restore equilibrium in the intestinal microbiota, decrease the duration of diarrhea, enhance respiratory symptoms such as cough and dyspnea, and reduce the length of hospitalization ( The potential application of microbiome or probiotic therapy holds promise as an emerging therapeutic approach due to its foundation on the multifactorial mechanism of action exhibited by beneficial bacteria in combating respiratory viral diseases ( Lactiplantibacillus plantarum strains and Pediococcus acidilactici shows a reduced nasopharyngeal viral load, lung infiltrates, and digestive and non-digestive symptoms duration

Furthermore, okra is abundant in minerals like potassium (303 mg), sodium (8 mg), copper (0.094 mg), calcium (81 mg), magnesium (57 mg), manganese (0.99 mg), iron (0.80 mg), selenium (0.7 mg) and phosphate (63 mg) contributing to cardiovascular, skeletal, metabolic, and immune health [31]