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Induced neural differentiation markers in mesenchymal stem cells Effect was concentration-dependent and reproducible Opens research applications in neural regeneration and stem cell biology

Vaccines 7 , 745752 (2008)

3.3.1 Individual use of nanoparticles in ferroptosis-mediated disease The injection of DFO in a model of Idiopathic pulmonary fibrosis (IPF) was found to increase survival (from 50% to 90%) and reverse the IPF phenotype in mice

These findings suggest that the increased membrane fluidity of metastatic tumor cells may underlie their heightened sensitivity to ferroptosis (47)

We speculate that in the presence of functional DNA repair mechanisms and physiological levels of FA, FA-caused DNA damage would be alleviated before it reaches the threshold required for triggering apoptosis