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doi:10.2337/db23-0377

However, they are excellent for studying the severe intestinal defects, systemic inflammation, and for screening of systemically administered drugs (Grubb and Livraghi-Butrico, 2022)

EDS causes an imbalance between tissue breakdown and repair, the body tends toward collagen breakdown because of the genetic defect

While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

A vibratome (Leica VT1200S, Leica Biosystems) was used to obtain 250 m thin acute brain slices containing Arc, identified by well-known landmarks