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In parallel, direct animal evidence shows that nanofabric reinforcement can mechanically stabilize intestinal anastomoses, reducing failure risk and improving local integrity (102)

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PMID: 255 LundMLEgerodKLEngelstoftMSDmytriyevaOTheodorssonEPatelBAet al

It mainly acts through binding to Toll-like receptors 2 ad 4 (Yin et al., 2019), to achieve the activation and recruitment of IL receptor-related kinases and phosphorylation of various immune-response-related protein kinases, ultimately resulting in immunomodulatory effects (Hoshino et al., 1999

The arylboronic acids substituted with electron-withdrawing and -donating functional groups afforded the corresponding aza-disulfides readily ( 6a 6f , 7b 7g , and 8h )