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In control mice, metastases were found in 3 out of 9 tumor-bearing mice, all of them being from tumors of the reproductive organs

Higgins, M.D

Notably, elevated levels of pro-inflammatory cytokines, such as interleukin-1beta(IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and interferon-gamma (IFN-), have been consistently observed in patients with ME/CFS [33, 34]

Proteomic analysis further demonstrated that hexokinase 2 (HK2), which catalyzes the first step of glycolysis by converting glucose to glucose-6-phosphate, was significantly downregulated at the protein level (Supplementary Fig

Citron, 2010)