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The antitumor functions of natural killer (NK) cells are upregulated by the expression of c-Myc proteins, which are required for IL-2/IL-12-induced NK cell metabolism and function 138

Indeed, pharmacological or genetic inhibition of EV release (using GW4869 [126] , Rab27A knockdown [71] , inhibition of HSP70/HSP90-dependent EV release with omeprazole [127] or atractylenolide I treatment [128] ) has been shown to inhibit adipocyte transdifferentiation and lipolysis and to attenuate weight loss in mouse models of lung and colon cancer, supporting the therapeutic potential of EV-targeted therapies to disrupt the metabolic interplay between tumor cells and adipocytes that fuels tumor progression and cancer cachexia

In addition, glutathione is clearly reduced in the aqueous humor of glaucoma patients with both IOP-dependent and IOP-independent disease subtypes

Nature (2010) 465(7300):966

Glutathione plays a critical role in cellular protection, antioxidant defense, and metabolic regulation , so reduced availability may coincide with noticeable changes in overall function