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The initial investigations aimed to identify components within gastric juice that contribute to the stomach's remarkable ability to protect and repair itself, a concept known as cytoprotection

the mice in the ROT+SP group received SP prophylaxis (300 g/g bw/d

However, ACSL4 is not necessary for all ferroptotic cell death, which means under special circumstances ferroptosis is able to be induced in ACSL4-depleted cells ( Ferroptosis is induced due to lipid peroxidation activated via non-enzyme-dependent (Fenton reaction) and enzyme-dependent processes