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Another retinoic acid analogue, 13-cis-retinoic acid exhibited modest therapeutic efficacy in recurrent GBM patients [69]

Demonstrates anti-inflammatory and cytoprotective properties in preclinical settings [6]

Undermining glutaminolysis bolsters chemotherapy while nrf2 promotes chemoresistance in kras-driven pancreatic cancers

Among tryptophan metabolites, serotonin (5-HT) is known to aggravate fibrosis by enhancing inflammation, neutrophil infiltration, oxidative stress, and upregulating TGF-1 and type I collagen [113]