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Recent studies have revealed that dysregulation of mitochondrial dynamicsincluding impaired mitophagy, imbalances in mitochondrial fusion and fission, and defects in mitochondrial biogenesisis closely associated with CRC initiation, progression, and resistance to therapy [46]

ISSN 1096-7192

Blood 116: 24762483 Moldoveanu D, Ramsay L, Lajoie M, AndersonTrocme L, Lingrand M, Berry D, Perus LJM, Wei Y, Moraes C, Alkallas R et al (2022) Spatially mapping the immune landscape of melanoma using imaging mass cytometry

Endogenous (e.g., inflammation) and exogenous (e.g., diet components, toxicants, or drugs) factors can increase intestinal permeability and cause the formation of a so-called leaky gut. The latter is characterized by the penetration of food antigens, commensals, or pathogenic bacteria into the blood, causing the development of inflammation (Vanuytsel et al., 2021)

What to look out for The recommended daily intake for vitamin C is much lowerthan what most supplements provide