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Xie noted that saikosaponin A can dose-dependently decrease the expression of multi-drug resistant protein P-glycoprotein (P-GP) in the temporal cortex and hippocampus, thereby reducing the level of refractory epilepsy caused by pirocarbine (Yu et al., 2012

Environ Sci Pollut Res 22:1436714371

doi:10.1016/S0731-7085(02)00142-5 93

Amino acids in excess of the quantities needed for the synthesis of protein and other nitrogen containing metabolites are neither stored nor excreted

Only NTP (1990) commented on intratubular material and noted that the tubules were empty or contained wisps of eosinophilic material. Maltoni et al